Anthelmintic drug discovery: target identification, screening methods and the role of open science

• Frederick A. Partridge,
• Ruth Forman,
• Carole J. R. Bataille,
• Graham M. Wynne,
• Marina Nick,
• Angela J. Russell,
• Kathryn J. Else and
• David B. Sattelle

Beilstein J. Org. Chem. 2020, 16, 1203–1224, doi:10.3762/bjoc.16.105

• , which relies on mass scale administration of a single dose treatment to undiagnosed individuals; otherwise known as mass drug administration (MDA) [22][23][24]. MDA programs are the cornerstone control strategy for these infections and usually target treatment to pre-school or school-attending children

Assessing the possibilities of designing a unified multistep continuous flow synthesis platform

• Mrityunjay K. Sharma,
• Roopashri B. Acharya,
• Chinmay A. Shukla and
• Amol A. Kulkarni

Beilstein J. Org. Chem. 2018, 14, 1917–1936, doi:10.3762/bjoc.14.166

• volume in the overall system. This would enhance the residence time, demand more safety features and also need more inventory. A larger dead volume has its own challenges. Control strategy: Devising a control strategy for a unified synthesis platform itself will be the most complex task. The complexity

• will originate from the varied control structures needed for individual synthesis sequence. For every reaction sequence verification of the sensitivity bounds on the specific control, strategy has to be developed for optimum performance of the setup. Scale of operation: Throughput for any targeted

• ) arrangement of various components in 3D space is critical, (iii) needs very complex control strategy, (iv) minimizing the pipeline length during component assembly is challenging to optimize the residence time variation and will handle more chemicals than conventional systems, (v) relatively large amount feed

Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic

• Chinmay A. Shukla and
• Amol A. Kulkarni

Beilstein J. Org. Chem. 2017, 13, 960–987, doi:10.3762/bjoc.13.97

• , optimization and process control. Subsequently, we have critically reviewed a few multistep flow synthesis and suggested a possible control strategy to be implemented so that it helps to reliably transfer the laboratory-scale synthesis strategy to a pilot scale at its optimum conditions. Due to the vast

• scale of operation. This classification will cover the broader range in the multistep synthesis literature. Keywords: automation; control strategy; flow chemistry; in-line monitoring; multistep synthesis optimization; Introduction Multistep flow synthesis In the recent time the concept of flow

• but the objective is to maintain a steady state process at optimal conditions through an appropriate control strategy. In general, automated control strategies are commonly implemented for bench scale, pilot scale, and commercial scale manufacturing of chemicals, and not at laboratory scale. However